《国际循环》：因此除了降压作用外，还有亚临床器官保护作用？

     <International Circulation>: So beside the effect of lowering the blood pressure， there also is a subclinical organic protection….

    Williams教授：是的，我认为这些阻断肾素系统的药物中很多还会减少白蛋白尿，并逆转异常的血管和心脏结构，而这些作用对长期降低心血管风险可能是重要的，因此这是为何我们喜欢在血压治疗中应用肾素-血管紧张素系统阻滞剂，无论是以单药治疗或联合治疗的形式。我认为目前OBS有最多的数据和最好的耐受性。但我想肾素抑制剂也有优异的耐受性，甚至很可能有更长的作用时间。因此我们期待看到这是否会转化为更好的结果。
 

   Prof.  Williams： Yeah， I think many of these drugs that block the renin system also reduce albuminurea and also reverse abnormal vascular and cardiac structure， and these things are likely to be important in the long term in reducing cardiovascular risk， so that’s why we like to use blockers of the rennin-angiotensin system in terms of treatment of blood pressure either as mono-therapy or combination. I think the OBS at the moment have the most data and the best tolerability. But I think the renin inhibitors also have excellent tolerability， probably even longer duration of action. So it’s going to be interesting to see whether that translates into better outcomes.

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